Mechanism of CCL21/CCL19-CCR7 as a Key Regulatory Signaling Cassette for Non-Small Cell Lung Cancer Patients with Brain Metastasis

To elucidate the molecular mechanism underlying high metastasis rate of brain for non-small cell lung cancer patients and to establish a comprehensive differential gene profile metastasis. The differentially expressed genes were systematically investigated. enriched biological processes signaling pathways explored. protein-protein interaction network was constructed. Compared with primary cancer, demonstrated 352 majority as down-regulated ones (342) 10 up-regulated ones. Meanwhile, C-C motif chemokine ligand 21, 19, deleted in malignant tumors 1 gene, tryptase alpha/beta 1, lactotransferrin, complement component 4 binding protein alpha, 14, C-X-C 9, cluster differentiation 79A well membrane spanning 4-domains A1 significant (all down-regulated). including 19 played pivotal role cytokines 21 their closely associated receptors, receptor 7 could be detected expression levels line (A549). Inhibition using small interfering ribonucleic acid obviously repressed invasion but not proliferation apoptosis. procedure independent micro lethal-7a regulation. This study hypothesized an innovative axis (C-C 21/C-C 19-C-C 7) provided beneficial strategy better understanding metastases clinic.